Nexen FB
Brand names,
Nexen FB
Analogs
Nexen FB
Brand Names Mixture
Nexen FB
Chemical_Formula
C24H31ClO7
Nexen FB
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Nexen FB
fda sheet
Nexen FB
msds (material safety sheet)
Nexen FB
Synthesis Reference
No information avaliable
Nexen FB
Molecular Weight
466.951 g/mol
Nexen FB
Melting Point
220-224 oC
Nexen FB
H2O Solubility
5 mg/mL
Nexen FB
State
Solid
Nexen FB
LogP
4.004
Nexen FB
Dosage Forms
Solution; Spray
Nexen FB
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Nexen FB
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Nexen FB
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Nexen FB
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Nexen FB
Patient Information
Nexen FB
Organisms Affected
Humans and other mammals