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Jacutin Brand names, Jacutin Analogs

Jacutin Brand Names Mixture

  • No information avaliable

Jacutin Chemical_Formula

C24H31ClO7

Jacutin RX_link

http://www.rxlist.com/cgi/generic2/lotemax.htm

Jacutin fda sheet

Jacutin FDA

Jacutin msds (material safety sheet)

Jacutin MSDS

Jacutin Synthesis Reference

No information avaliable

Jacutin Molecular Weight

466.951 g/mol

Jacutin Melting Point

220-224 oC

Jacutin H2O Solubility

5 mg/mL

Jacutin State

Solid

Jacutin LogP

4.004

Jacutin Dosage Forms

Solution; Spray

Jacutin Indication

As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.

Jacutin Pharmacology

Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.

Jacutin Absorption

Very limited systemic absorption, but good absorption at the point of delivery.

Jacutin side effects and Toxicity

Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.

Jacutin Patient Information

Jacutin Organisms Affected

Humans and other mammals