Jacutin
Brand names,
Jacutin
Analogs
Jacutin
Brand Names Mixture
Jacutin
Chemical_Formula
C24H31ClO7
Jacutin
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Jacutin
fda sheet
Jacutin
msds (material safety sheet)
Jacutin
Synthesis Reference
No information avaliable
Jacutin
Molecular Weight
466.951 g/mol
Jacutin
Melting Point
220-224 oC
Jacutin
H2O Solubility
5 mg/mL
Jacutin
State
Solid
Jacutin
LogP
4.004
Jacutin
Dosage Forms
Solution; Spray
Jacutin
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Jacutin
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Jacutin
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Jacutin
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Jacutin
Patient Information
Jacutin
Organisms Affected
Humans and other mammals