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Gamma-Col Brand names, Gamma-Col Analogs

Gamma-Col Brand Names Mixture

  • No information avaliable

Gamma-Col Chemical_Formula

C24H31ClO7

Gamma-Col RX_link

http://www.rxlist.com/cgi/generic2/lotemax.htm

Gamma-Col fda sheet

Gamma-Col FDA

Gamma-Col msds (material safety sheet)

Gamma-Col MSDS

Gamma-Col Synthesis Reference

No information avaliable

Gamma-Col Molecular Weight

466.951 g/mol

Gamma-Col Melting Point

220-224 oC

Gamma-Col H2O Solubility

5 mg/mL

Gamma-Col State

Solid

Gamma-Col LogP

4.004

Gamma-Col Dosage Forms

Solution; Spray

Gamma-Col Indication

As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.

Gamma-Col Pharmacology

Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.

Gamma-Col Absorption

Very limited systemic absorption, but good absorption at the point of delivery.

Gamma-Col side effects and Toxicity

Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.

Gamma-Col Patient Information

Gamma-Col Organisms Affected

Humans and other mammals