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HCH Brand names, HCH Analogs

HCH Brand Names Mixture

  • No information avaliable

HCH Chemical_Formula

C24H31ClO7

HCH RX_link

http://www.rxlist.com/cgi/generic2/lotemax.htm

HCH fda sheet

HCH FDA

HCH msds (material safety sheet)

HCH MSDS

HCH Synthesis Reference

No information avaliable

HCH Molecular Weight

466.951 g/mol

HCH Melting Point

220-224 oC

HCH H2O Solubility

5 mg/mL

HCH State

Solid

HCH LogP

4.004

HCH Dosage Forms

Solution; Spray

HCH Indication

As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.

HCH Pharmacology

Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.

HCH Absorption

Very limited systemic absorption, but good absorption at the point of delivery.

HCH side effects and Toxicity

Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.

HCH Patient Information

HCH Organisms Affected

Humans and other mammals