Hexyclan
Brand names,
Hexyclan
Analogs
Hexyclan
Brand Names Mixture
Hexyclan
Chemical_Formula
C24H31ClO7
Hexyclan
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Hexyclan
fda sheet
Hexyclan
msds (material safety sheet)
Hexyclan
Synthesis Reference
No information avaliable
Hexyclan
Molecular Weight
466.951 g/mol
Hexyclan
Melting Point
220-224 oC
Hexyclan
H2O Solubility
5 mg/mL
Hexyclan
State
Solid
Hexyclan
LogP
4.004
Hexyclan
Dosage Forms
Solution; Spray
Hexyclan
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Hexyclan
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Hexyclan
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Hexyclan
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Hexyclan
Patient Information
Hexyclan
Organisms Affected
Humans and other mammals