Entomoxan
Brand names,
Entomoxan
Analogs
Entomoxan
Brand Names Mixture
Entomoxan
Chemical_Formula
C24H31ClO7
Entomoxan
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Entomoxan
fda sheet
Entomoxan
msds (material safety sheet)
Entomoxan
Synthesis Reference
No information avaliable
Entomoxan
Molecular Weight
466.951 g/mol
Entomoxan
Melting Point
220-224 oC
Entomoxan
H2O Solubility
5 mg/mL
Entomoxan
State
Solid
Entomoxan
LogP
4.004
Entomoxan
Dosage Forms
Solution; Spray
Entomoxan
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Entomoxan
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Entomoxan
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Entomoxan
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Entomoxan
Patient Information
Entomoxan
Organisms Affected
Humans and other mammals