Neo-Scabicidol
Brand names,
Neo-Scabicidol
Analogs
Neo-Scabicidol
Brand Names Mixture
Neo-Scabicidol
Chemical_Formula
C24H31ClO7
Neo-Scabicidol
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Neo-Scabicidol
fda sheet
Neo-Scabicidol
msds (material safety sheet)
Neo-Scabicidol
Synthesis Reference
No information avaliable
Neo-Scabicidol
Molecular Weight
466.951 g/mol
Neo-Scabicidol
Melting Point
220-224 oC
Neo-Scabicidol
H2O Solubility
5 mg/mL
Neo-Scabicidol
State
Solid
Neo-Scabicidol
LogP
4.004
Neo-Scabicidol
Dosage Forms
Solution; Spray
Neo-Scabicidol
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Neo-Scabicidol
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Neo-Scabicidol
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Neo-Scabicidol
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Neo-Scabicidol
Patient Information
Neo-Scabicidol
Organisms Affected
Humans and other mammals