Ameisenmittel merck
Brand names,
Ameisenmittel merck
Analogs
Ameisenmittel merck
Brand Names Mixture
Ameisenmittel merck
Chemical_Formula
C24H31ClO7
Ameisenmittel merck
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Ameisenmittel merck
fda sheet
Ameisenmittel merck
msds (material safety sheet)
Ameisenmittel merck
Synthesis Reference
No information avaliable
Ameisenmittel merck
Molecular Weight
466.951 g/mol
Ameisenmittel merck
Melting Point
220-224 oC
Ameisenmittel merck
H2O Solubility
5 mg/mL
Ameisenmittel merck
State
Solid
Ameisenmittel merck
LogP
4.004
Ameisenmittel merck
Dosage Forms
Solution; Spray
Ameisenmittel merck
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Ameisenmittel merck
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Ameisenmittel merck
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Ameisenmittel merck
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Ameisenmittel merck
Patient Information
Ameisenmittel merck
Organisms Affected
Humans and other mammals