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Nexol-E Brand names, Nexol-E Analogs

Nexol-E Brand Names Mixture

  • No information avaliable

Nexol-E Chemical_Formula

C24H31ClO7

Nexol-E RX_link

http://www.rxlist.com/cgi/generic2/lotemax.htm

Nexol-E fda sheet

Nexol-E FDA

Nexol-E msds (material safety sheet)

Nexol-E MSDS

Nexol-E Synthesis Reference

No information avaliable

Nexol-E Molecular Weight

466.951 g/mol

Nexol-E Melting Point

220-224 oC

Nexol-E H2O Solubility

5 mg/mL

Nexol-E State

Solid

Nexol-E LogP

4.004

Nexol-E Dosage Forms

Solution; Spray

Nexol-E Indication

As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.

Nexol-E Pharmacology

Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.

Nexol-E Absorption

Very limited systemic absorption, but good absorption at the point of delivery.

Nexol-E side effects and Toxicity

Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.

Nexol-E Patient Information

Nexol-E Organisms Affected

Humans and other mammals