Hexaverm
Brand names,
Hexaverm
Analogs
Hexaverm
Brand Names Mixture
Hexaverm
Chemical_Formula
C24H31ClO7
Hexaverm
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Hexaverm
fda sheet
Hexaverm
msds (material safety sheet)
Hexaverm
Synthesis Reference
No information avaliable
Hexaverm
Molecular Weight
466.951 g/mol
Hexaverm
Melting Point
220-224 oC
Hexaverm
H2O Solubility
5 mg/mL
Hexaverm
State
Solid
Hexaverm
LogP
4.004
Hexaverm
Dosage Forms
Solution; Spray
Hexaverm
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Hexaverm
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Hexaverm
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Hexaverm
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Hexaverm
Patient Information
Hexaverm
Organisms Affected
Humans and other mammals