Gammalin
Brand names,
Gammalin
Analogs
Gammalin
Brand Names Mixture
Gammalin
Chemical_Formula
C24H31ClO7
Gammalin
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Gammalin
fda sheet
Gammalin
msds (material safety sheet)
Gammalin
Synthesis Reference
No information avaliable
Gammalin
Molecular Weight
466.951 g/mol
Gammalin
Melting Point
220-224 oC
Gammalin
H2O Solubility
5 mg/mL
Gammalin
State
Solid
Gammalin
LogP
4.004
Gammalin
Dosage Forms
Solution; Spray
Gammalin
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Gammalin
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Gammalin
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Gammalin
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
Gammalin
Patient Information
Gammalin
Organisms Affected
Humans and other mammals