Thionex
Brand names,
Thionex
Analogs
Thionex
Brand Names Mixture
Thionex
Chemical_Formula
C24H31ClO7
Thionex
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
Thionex
fda sheet
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msds (material safety sheet)
Thionex
Synthesis Reference
No information avaliable
Thionex
Molecular Weight
466.951 g/mol
Thionex
Melting Point
220-224 oC
Thionex
H2O Solubility
5 mg/mL
Thionex
State
Solid
Thionex
LogP
4.004
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Dosage Forms
Solution; Spray
Thionex
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
Thionex
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
Thionex
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
Thionex
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
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Patient Information
Thionex
Organisms Affected
Humans and other mammals