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Isotox Brand names, Isotox Analogs

Isotox Brand Names Mixture

  • No information avaliable

Isotox Chemical_Formula

C24H31ClO7

Isotox RX_link

http://www.rxlist.com/cgi/generic2/lotemax.htm

Isotox fda sheet

Isotox FDA

Isotox msds (material safety sheet)

Isotox MSDS

Isotox Synthesis Reference

No information avaliable

Isotox Molecular Weight

466.951 g/mol

Isotox Melting Point

220-224 oC

Isotox H2O Solubility

5 mg/mL

Isotox State

Solid

Isotox LogP

4.004

Isotox Dosage Forms

Solution; Spray

Isotox Indication

As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.

Isotox Pharmacology

Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.

Isotox Absorption

Very limited systemic absorption, but good absorption at the point of delivery.

Isotox side effects and Toxicity

Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.

Isotox Patient Information

Isotox Organisms Affected

Humans and other mammals