PMS Lindane
Brand names,
PMS Lindane
Analogs
PMS Lindane
Brand Names Mixture
PMS Lindane
Chemical_Formula
C24H31ClO7
PMS Lindane
RX_link
http://www.rxlist.com/cgi/generic2/lotemax.htm
PMS Lindane
fda sheet
PMS Lindane
msds (material safety sheet)
PMS Lindane
Synthesis Reference
No information avaliable
PMS Lindane
Molecular Weight
466.951 g/mol
PMS Lindane
Melting Point
220-224 oC
PMS Lindane
H2O Solubility
5 mg/mL
PMS Lindane
State
Solid
PMS Lindane
LogP
4.004
PMS Lindane
Dosage Forms
Solution; Spray
PMS Lindane
Indication
As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, used for the treatment and management of seasonal allergic rhinitis.
PMS Lindane
Pharmacology
Loteprednol etabonate (LE) is a "soft" steroid belonging to a unique class of glucocorticoids. LE possesses a metabolically labile 17 beta-chloromethyl ester function which was designed in order to be hydrolyzed to an inactive carboxylic acid moiety. This inactive metabolite is more hydrophilic and is thus readily eliminated from the body. Loteprednol etabonate has good ocular permeation properties and good skin permeation properties similar to "hard" steroids. It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis.
PMS Lindane
Absorption
Very limited systemic absorption, but good absorption at the point of delivery.
PMS Lindane
side effects and Toxicity
Adverse effects include abnormal vision / blurring, burning on instillation, chemosis, discharge, dry eyes, epiphora, foreign body sensation, itching, injection, and photophobia.
PMS Lindane
Patient Information
PMS Lindane
Organisms Affected
Humans and other mammals