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Prometazin Brand names, Prometazin Analogs

Prometazin Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Prometazin Chemical_Formula


Prometazin RX_link

Prometazin fda sheet

Prometazin FDA

Prometazin msds (material safety sheet)

Prometazin Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Prometazin Molecular Weight

284.42 g/mol

Prometazin Melting Point


Prometazin H2O Solubility

Freely soluble

Prometazin State


Prometazin LogP


Prometazin Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Prometazin Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Prometazin Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Prometazin Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Prometazin side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Prometazin Patient Information

Prometazin Organisms Affected

Humans and other mammals