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Diphergan Brand names, Diphergan Analogs

Diphergan Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Diphergan Chemical_Formula


Diphergan RX_link


Diphergan fda sheet

Diphergan FDA

Diphergan msds (material safety sheet)

Diphergan Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Diphergan Molecular Weight

284.42 g/mol

Diphergan Melting Point


Diphergan H2O Solubility

Freely soluble

Diphergan State


Diphergan LogP


Diphergan Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Diphergan Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Diphergan Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Diphergan Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Diphergan side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Diphergan Patient Information

Diphergan Organisms Affected

Humans and other mammals