Fellozine
Brand names,
Fellozine
Analogs
Fellozine
Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Fellozine
Chemical_Formula
C17H20N2S
Fellozine
RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Fellozine
fda sheet
Fellozine
msds (material safety sheet)
Fellozine
Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Fellozine
Molecular Weight
284.42 g/mol
Fellozine
Melting Point
60oC
Fellozine
H2O Solubility
Freely soluble
Fellozine
State
Solid
Fellozine
LogP
4.946
Fellozine
Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Fellozine
Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Fellozine
Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Fellozine
Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Fellozine
side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Fellozine
Patient Information
Fellozine
Organisms Affected
Humans and other mammals