Promezathine en es it fr

Promezathine Brand names, Promezathine Analogs

Promezathine Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Promezathine Chemical_Formula


Promezathine RX_link

Promezathine fda sheet

Promezathine FDA

Promezathine msds (material safety sheet)

Promezathine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Promezathine Molecular Weight

284.42 g/mol

Promezathine Melting Point


Promezathine H2O Solubility

Freely soluble

Promezathine State


Promezathine LogP


Promezathine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Promezathine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Promezathine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Promezathine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Promezathine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Promezathine Patient Information

Promezathine Organisms Affected

Humans and other mammals