Promezathine
Promezathine Brand names, Promezathine Analogs
- Allergan
- Aprobit
- Atosil
- Avomine
- Dimapp
- Diphergan
- Diprazine
- Diprozin
- Dorme
- Duplamin
- Fargan
- Fellozine
- Fenazil
- Fenergan
- Fenetazina
- Genphen
- Hiberna
- Histargan
- Iergigan
- Isophenergan
- Isopromethazine
- Lercigan
- Lergigan
- Lilly 1516
- Mymethazine Fortis
- Phargan
- Phenargan
- Phencen
- Phenergan
- Phenergan Fortis
- Phensedyl
- Pilpophen
- Pipolphen
- Proazaimine
- Proazamine
- Procit
- Promazinamide
- Prometasin
- Prometazin
- Prometh Fortis
- Prometh Plain
- Promethacon
- Promethaine
- Promethazin
- Promethazine Hcl
- Promethazine Plain
- Promethegan
- Promethiazine
- Promezathine
- Prorex
- Protazine
- Prothazin
- Prothazine
- Provigan
- Pyrethia
- Pyrethiazine
- Remsed
- Romergan
- Synalgos
- Tanidil
- Thiergan
- Valergine
- Vallergine
- Zipan-25
Promezathine Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Promezathine Chemical_Formula
C17H20N2S
Promezathine RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Promezathine fda sheet
Promezathine msds (material safety sheet)
Promezathine Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Promezathine Molecular Weight
284.42 g/mol
Promezathine Melting Point
60oC
Promezathine H2O Solubility
Freely soluble
Promezathine State
Solid
Promezathine LogP
4.946
Promezathine Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Promezathine Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Promezathine Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Promezathine Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Promezathine side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Promezathine Patient Information
Promezathine Organisms Affected
Humans and other mammals
