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Thiergan Brand names, Thiergan Analogs

Thiergan Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Thiergan Chemical_Formula


Thiergan RX_link

Thiergan fda sheet

Thiergan FDA

Thiergan msds (material safety sheet)

Thiergan Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Thiergan Molecular Weight

284.42 g/mol

Thiergan Melting Point


Thiergan H2O Solubility

Freely soluble

Thiergan State


Thiergan LogP


Thiergan Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Thiergan Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Thiergan Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Thiergan Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Thiergan side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Thiergan Patient Information

Thiergan Organisms Affected

Humans and other mammals