Mymethazine Fortis
Brand names,
Mymethazine Fortis
Analogs
Mymethazine Fortis
Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Mymethazine Fortis
Chemical_Formula
C17H20N2S
Mymethazine Fortis
RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Mymethazine Fortis
fda sheet
Mymethazine Fortis
msds (material safety sheet)
Mymethazine Fortis
Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Mymethazine Fortis
Molecular Weight
284.42 g/mol
Mymethazine Fortis
Melting Point
60oC
Mymethazine Fortis
H2O Solubility
Freely soluble
Mymethazine Fortis
State
Solid
Mymethazine Fortis
LogP
4.946
Mymethazine Fortis
Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Mymethazine Fortis
Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Mymethazine Fortis
Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Mymethazine Fortis
Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Mymethazine Fortis
side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Mymethazine Fortis
Patient Information
Mymethazine Fortis
Organisms Affected
Humans and other mammals