Vallergine

Vallergine Brand names, Vallergine Analogs

Vallergine Brand Names Mixture

Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Vallergine Chemical_Formula

C₁₇H₂₀N₂S

Vallergine RX_link

http://www.rxlist.com/cgi/generic3/phenergan.htm

Vallergine fda sheet

Vallergine FDA

Vallergine msds (material safety sheet)

Vallergine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Vallergine Molecular Weight

284.42 g/mol

Vallergine Melting Point

60^oC

Vallergine H₂O Solubility

Freely soluble

Vallergine State

Solid

Vallergine LogP

4.946

Vallergine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Vallergine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Vallergine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Vallergine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Vallergine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD₅₀=55mg/kg (I.V. in mice)

Vallergine Patient Information

Vallergine Organisms Affected

Humans and other mammals