Phenergan Fortis
Brand names,
Phenergan Fortis
Analogs
Phenergan Fortis
Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Phenergan Fortis
Chemical_Formula
C17H20N2S
Phenergan Fortis
RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Phenergan Fortis
fda sheet
Phenergan Fortis
msds (material safety sheet)
Phenergan Fortis
Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Phenergan Fortis
Molecular Weight
284.42 g/mol
Phenergan Fortis
Melting Point
60oC
Phenergan Fortis
H2O Solubility
Freely soluble
Phenergan Fortis
State
Solid
Phenergan Fortis
LogP
4.946
Phenergan Fortis
Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Phenergan Fortis
Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Phenergan Fortis
Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Phenergan Fortis
Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Phenergan Fortis
side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Phenergan Fortis
Patient Information
Phenergan Fortis
Organisms Affected
Humans and other mammals