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Duplamin Brand names, Duplamin Analogs

Duplamin Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Duplamin Chemical_Formula


Duplamin RX_link


Duplamin fda sheet

Duplamin FDA

Duplamin msds (material safety sheet)

Duplamin Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Duplamin Molecular Weight

284.42 g/mol

Duplamin Melting Point


Duplamin H2O Solubility

Freely soluble

Duplamin State


Duplamin LogP


Duplamin Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Duplamin Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Duplamin Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Duplamin Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Duplamin side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Duplamin Patient Information

Duplamin Organisms Affected

Humans and other mammals