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Fenergan Brand names, Fenergan Analogs

Fenergan Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Fenergan Chemical_Formula


Fenergan RX_link


Fenergan fda sheet

Fenergan FDA

Fenergan msds (material safety sheet)

Fenergan Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Fenergan Molecular Weight

284.42 g/mol

Fenergan Melting Point


Fenergan H2O Solubility

Freely soluble

Fenergan State


Fenergan LogP


Fenergan Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Fenergan Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Fenergan Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Fenergan Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Fenergan side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Fenergan Patient Information

Fenergan Organisms Affected

Humans and other mammals