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Promazinamide Brand names, Promazinamide Analogs

Promazinamide Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Promazinamide Chemical_Formula


Promazinamide RX_link

Promazinamide fda sheet

Promazinamide FDA

Promazinamide msds (material safety sheet)

Promazinamide Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Promazinamide Molecular Weight

284.42 g/mol

Promazinamide Melting Point


Promazinamide H2O Solubility

Freely soluble

Promazinamide State


Promazinamide LogP


Promazinamide Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Promazinamide Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Promazinamide Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Promazinamide Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Promazinamide side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Promazinamide Patient Information

Promazinamide Organisms Affected

Humans and other mammals