Promazinamide
Promazinamide Brand names, Promazinamide Analogs
- Allergan
- Aprobit
- Atosil
- Avomine
- Dimapp
- Diphergan
- Diprazine
- Diprozin
- Dorme
- Duplamin
- Fargan
- Fellozine
- Fenazil
- Fenergan
- Fenetazina
- Genphen
- Hiberna
- Histargan
- Iergigan
- Isophenergan
- Isopromethazine
- Lercigan
- Lergigan
- Lilly 1516
- Mymethazine Fortis
- Phargan
- Phenargan
- Phencen
- Phenergan
- Phenergan Fortis
- Phensedyl
- Pilpophen
- Pipolphen
- Proazaimine
- Proazamine
- Procit
- Promazinamide
- Prometasin
- Prometazin
- Prometh Fortis
- Prometh Plain
- Promethacon
- Promethaine
- Promethazin
- Promethazine Hcl
- Promethazine Plain
- Promethegan
- Promethiazine
- Promezathine
- Prorex
- Protazine
- Prothazin
- Prothazine
- Provigan
- Pyrethia
- Pyrethiazine
- Remsed
- Romergan
- Synalgos
- Tanidil
- Thiergan
- Valergine
- Vallergine
- Zipan-25
Promazinamide Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Promazinamide Chemical_Formula
C17H20N2S
Promazinamide RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Promazinamide fda sheet
Promazinamide msds (material safety sheet)
Promazinamide Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Promazinamide Molecular Weight
284.42 g/mol
Promazinamide Melting Point
60oC
Promazinamide H2O Solubility
Freely soluble
Promazinamide State
Solid
Promazinamide LogP
4.946
Promazinamide Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Promazinamide Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Promazinamide Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Promazinamide Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Promazinamide side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Promazinamide Patient Information
Promazinamide Organisms Affected
Humans and other mammals
