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Hiberna Brand names, Hiberna Analogs

Hiberna Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Hiberna Chemical_Formula


Hiberna RX_link


Hiberna fda sheet

Hiberna FDA

Hiberna msds (material safety sheet)

Hiberna Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Hiberna Molecular Weight

284.42 g/mol

Hiberna Melting Point


Hiberna H2O Solubility

Freely soluble

Hiberna State


Hiberna LogP


Hiberna Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Hiberna Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Hiberna Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Hiberna Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Hiberna side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Hiberna Patient Information

Hiberna Organisms Affected

Humans and other mammals