Prometh Plain

Prometh Plain Brand names, Prometh Plain Analogs

Prometh Plain Brand Names Mixture

Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Prometh Plain Chemical_Formula

C₁₇H₂₀N₂S

Prometh Plain RX_link

http://www.rxlist.com/cgi/generic3/phenergan.htm

Prometh Plain fda sheet

Prometh_Plain FDA

Prometh Plain msds (material safety sheet)

Prometh Plain Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Prometh Plain Molecular Weight

284.42 g/mol

Prometh Plain Melting Point

60^oC

Prometh Plain H₂O Solubility

Freely soluble

Prometh Plain State

Solid

Prometh Plain LogP

4.946

Prometh Plain Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Prometh Plain Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Prometh Plain Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Prometh Plain Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Prometh Plain side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD₅₀=55mg/kg (I.V. in mice)

Prometh Plain Patient Information

Prometh Plain Organisms Affected

Humans and other mammals