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Phenergan Brand names, Phenergan Analogs

Phenergan Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Phenergan Chemical_Formula


Phenergan RX_link

Phenergan fda sheet

Phenergan FDA

Phenergan msds (material safety sheet)

Phenergan Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Phenergan Molecular Weight

284.42 g/mol

Phenergan Melting Point


Phenergan H2O Solubility

Freely soluble

Phenergan State


Phenergan LogP


Phenergan Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Phenergan Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Phenergan Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Phenergan Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Phenergan side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Phenergan Patient Information

Phenergan Organisms Affected

Humans and other mammals