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Avomine Brand names, Avomine Analogs

Avomine Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Avomine Chemical_Formula


Avomine RX_link


Avomine fda sheet

Avomine FDA

Avomine msds (material safety sheet)

Avomine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Avomine Molecular Weight

284.42 g/mol

Avomine Melting Point


Avomine H2O Solubility

Freely soluble

Avomine State


Avomine LogP


Avomine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Avomine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Avomine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Avomine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Avomine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Avomine Patient Information

Avomine Organisms Affected

Humans and other mammals