Diprazine en es it fr

Diprazine Brand names, Diprazine Analogs

Diprazine Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Diprazine Chemical_Formula


Diprazine RX_link


Diprazine fda sheet

Diprazine FDA

Diprazine msds (material safety sheet)

Diprazine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Diprazine Molecular Weight

284.42 g/mol

Diprazine Melting Point


Diprazine H2O Solubility

Freely soluble

Diprazine State


Diprazine LogP


Diprazine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Diprazine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Diprazine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Diprazine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Diprazine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Diprazine Patient Information

Diprazine Organisms Affected

Humans and other mammals