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Proazaimine Brand names, Proazaimine Analogs

Proazaimine Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Proazaimine Chemical_Formula


Proazaimine RX_link

Proazaimine fda sheet

Proazaimine FDA

Proazaimine msds (material safety sheet)

Proazaimine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Proazaimine Molecular Weight

284.42 g/mol

Proazaimine Melting Point


Proazaimine H2O Solubility

Freely soluble

Proazaimine State


Proazaimine LogP


Proazaimine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Proazaimine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Proazaimine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Proazaimine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Proazaimine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Proazaimine Patient Information

Proazaimine Organisms Affected

Humans and other mammals