Promethazine Plain

Promethazine Plain Brand names, Promethazine Plain Analogs

Promethazine Plain Brand Names Mixture

Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Promethazine Plain Chemical_Formula

C₁₇H₂₀N₂S

Promethazine Plain RX_link

http://www.rxlist.com/cgi/generic3/phenergan.htm

Promethazine Plain fda sheet

Promethazine_Plain FDA

Promethazine Plain msds (material safety sheet)

Promethazine Plain Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Promethazine Plain Molecular Weight

284.42 g/mol

Promethazine Plain Melting Point

60^oC

Promethazine Plain H₂O Solubility

Freely soluble

Promethazine Plain State

Solid

Promethazine Plain LogP

4.946

Promethazine Plain Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Promethazine Plain Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Promethazine Plain Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Promethazine Plain Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Promethazine Plain side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD₅₀=55mg/kg (I.V. in mice)

Promethazine Plain Patient Information

Promethazine Plain Organisms Affected

Humans and other mammals