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Proazamine Brand names, Proazamine Analogs

Proazamine Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Proazamine Chemical_Formula


Proazamine RX_link

Proazamine fda sheet

Proazamine FDA

Proazamine msds (material safety sheet)

Proazamine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Proazamine Molecular Weight

284.42 g/mol

Proazamine Melting Point


Proazamine H2O Solubility

Freely soluble

Proazamine State


Proazamine LogP


Proazamine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Proazamine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Proazamine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Proazamine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Proazamine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Proazamine Patient Information

Proazamine Organisms Affected

Humans and other mammals