Prometh Fortis
Brand names,
Prometh Fortis
Analogs
Prometh Fortis
Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Prometh Fortis
Chemical_Formula
C17H20N2S
Prometh Fortis
RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Prometh Fortis
fda sheet
Prometh Fortis
msds (material safety sheet)
Prometh Fortis
Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Prometh Fortis
Molecular Weight
284.42 g/mol
Prometh Fortis
Melting Point
60oC
Prometh Fortis
H2O Solubility
Freely soluble
Prometh Fortis
State
Solid
Prometh Fortis
LogP
4.946
Prometh Fortis
Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Prometh Fortis
Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Prometh Fortis
Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Prometh Fortis
Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Prometh Fortis
side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Prometh Fortis
Patient Information
Prometh Fortis
Organisms Affected
Humans and other mammals