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Fenazil Brand names, Fenazil Analogs

Fenazil Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Fenazil Chemical_Formula


Fenazil RX_link


Fenazil fda sheet

Fenazil FDA

Fenazil msds (material safety sheet)

Fenazil Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Fenazil Molecular Weight

284.42 g/mol

Fenazil Melting Point


Fenazil H2O Solubility

Freely soluble

Fenazil State


Fenazil LogP


Fenazil Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Fenazil Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Fenazil Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Fenazil Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Fenazil side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Fenazil Patient Information

Fenazil Organisms Affected

Humans and other mammals