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Romergan Brand names, Romergan Analogs

Romergan Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Romergan Chemical_Formula


Romergan RX_link

Romergan fda sheet

Romergan FDA

Romergan msds (material safety sheet)

Romergan Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Romergan Molecular Weight

284.42 g/mol

Romergan Melting Point


Romergan H2O Solubility

Freely soluble

Romergan State


Romergan LogP


Romergan Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Romergan Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Romergan Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Romergan Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Romergan side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Romergan Patient Information

Romergan Organisms Affected

Humans and other mammals