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Prothazin Brand names, Prothazin Analogs

Prothazin Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Prothazin Chemical_Formula


Prothazin RX_link

Prothazin fda sheet

Prothazin FDA

Prothazin msds (material safety sheet)

Prothazin Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Prothazin Molecular Weight

284.42 g/mol

Prothazin Melting Point


Prothazin H2O Solubility

Freely soluble

Prothazin State


Prothazin LogP


Prothazin Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Prothazin Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Prothazin Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Prothazin Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Prothazin side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Prothazin Patient Information

Prothazin Organisms Affected

Humans and other mammals