Aprobit en es it fr

Aprobit Brand names, Aprobit Analogs

Aprobit Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Aprobit Chemical_Formula


Aprobit RX_link


Aprobit fda sheet

Aprobit FDA

Aprobit msds (material safety sheet)

Aprobit Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Aprobit Molecular Weight

284.42 g/mol

Aprobit Melting Point


Aprobit H2O Solubility

Freely soluble

Aprobit State


Aprobit LogP


Aprobit Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Aprobit Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Aprobit Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Aprobit Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Aprobit side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Aprobit Patient Information

Aprobit Organisms Affected

Humans and other mammals