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Atosil Brand names, Atosil Analogs

Atosil Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Atosil Chemical_Formula


Atosil RX_link

Atosil fda sheet

Atosil FDA

Atosil msds (material safety sheet)

Atosil Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Atosil Molecular Weight

284.42 g/mol

Atosil Melting Point


Atosil H2O Solubility

Freely soluble

Atosil State


Atosil LogP


Atosil Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Atosil Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Atosil Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Atosil Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Atosil side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Atosil Patient Information

Atosil Organisms Affected

Humans and other mammals