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Promethaine Brand names, Promethaine Analogs

Promethaine Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Promethaine Chemical_Formula


Promethaine RX_link

Promethaine fda sheet

Promethaine FDA

Promethaine msds (material safety sheet)

Promethaine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Promethaine Molecular Weight

284.42 g/mol

Promethaine Melting Point


Promethaine H2O Solubility

Freely soluble

Promethaine State


Promethaine LogP


Promethaine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Promethaine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Promethaine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Promethaine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Promethaine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Promethaine Patient Information

Promethaine Organisms Affected

Humans and other mammals