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Protazine Brand names, Protazine Analogs

Protazine Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Protazine Chemical_Formula


Protazine RX_link

Protazine fda sheet

Protazine FDA

Protazine msds (material safety sheet)

Protazine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Protazine Molecular Weight

284.42 g/mol

Protazine Melting Point


Protazine H2O Solubility

Freely soluble

Protazine State


Protazine LogP


Protazine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Protazine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Protazine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Protazine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Protazine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Protazine Patient Information

Protazine Organisms Affected

Humans and other mammals