Protazine
Protazine Brand names, Protazine Analogs
- Allergan
- Aprobit
- Atosil
- Avomine
- Dimapp
- Diphergan
- Diprazine
- Diprozin
- Dorme
- Duplamin
- Fargan
- Fellozine
- Fenazil
- Fenergan
- Fenetazina
- Genphen
- Hiberna
- Histargan
- Iergigan
- Isophenergan
- Isopromethazine
- Lercigan
- Lergigan
- Lilly 1516
- Mymethazine Fortis
- Phargan
- Phenargan
- Phencen
- Phenergan
- Phenergan Fortis
- Phensedyl
- Pilpophen
- Pipolphen
- Proazaimine
- Proazamine
- Procit
- Promazinamide
- Prometasin
- Prometazin
- Prometh Fortis
- Prometh Plain
- Promethacon
- Promethaine
- Promethazin
- Promethazine Hcl
- Promethazine Plain
- Promethegan
- Promethiazine
- Promezathine
- Prorex
- Protazine
- Prothazin
- Prothazine
- Provigan
- Pyrethia
- Pyrethiazine
- Remsed
- Romergan
- Synalgos
- Tanidil
- Thiergan
- Valergine
- Vallergine
- Zipan-25
Protazine Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Protazine Chemical_Formula
C17H20N2S
Protazine RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Protazine fda sheet
Protazine msds (material safety sheet)
Protazine Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Protazine Molecular Weight
284.42 g/mol
Protazine Melting Point
60oC
Protazine H2O Solubility
Freely soluble
Protazine State
Solid
Protazine LogP
4.946
Protazine Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Protazine Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Protazine Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Protazine Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Protazine side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Protazine Patient Information
Protazine Organisms Affected
Humans and other mammals
