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Isophenergan Brand names, Isophenergan Analogs

Isophenergan Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Isophenergan Chemical_Formula


Isophenergan RX_link

Isophenergan fda sheet

Isophenergan FDA

Isophenergan msds (material safety sheet)

Isophenergan Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Isophenergan Molecular Weight

284.42 g/mol

Isophenergan Melting Point


Isophenergan H2O Solubility

Freely soluble

Isophenergan State


Isophenergan LogP


Isophenergan Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Isophenergan Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Isophenergan Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Isophenergan Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Isophenergan side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Isophenergan Patient Information

Isophenergan Organisms Affected

Humans and other mammals