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Histargan Brand names, Histargan Analogs

Histargan Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Histargan Chemical_Formula


Histargan RX_link


Histargan fda sheet

Histargan FDA

Histargan msds (material safety sheet)

Histargan Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Histargan Molecular Weight

284.42 g/mol

Histargan Melting Point


Histargan H2O Solubility

Freely soluble

Histargan State


Histargan LogP


Histargan Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Histargan Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Histargan Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Histargan Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Histargan side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Histargan Patient Information

Histargan Organisms Affected

Humans and other mammals