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Valergine Brand names, Valergine Analogs

Valergine Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Valergine Chemical_Formula


Valergine RX_link

Valergine fda sheet

Valergine FDA

Valergine msds (material safety sheet)

Valergine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Valergine Molecular Weight

284.42 g/mol

Valergine Melting Point


Valergine H2O Solubility

Freely soluble

Valergine State


Valergine LogP


Valergine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Valergine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Valergine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Valergine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Valergine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Valergine Patient Information

Valergine Organisms Affected

Humans and other mammals