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Pilpophen Brand names, Pilpophen Analogs

Pilpophen Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Pilpophen Chemical_Formula


Pilpophen RX_link


Pilpophen fda sheet

Pilpophen FDA

Pilpophen msds (material safety sheet)

Pilpophen Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Pilpophen Molecular Weight

284.42 g/mol

Pilpophen Melting Point


Pilpophen H2O Solubility

Freely soluble

Pilpophen State


Pilpophen LogP


Pilpophen Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Pilpophen Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Pilpophen Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Pilpophen Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Pilpophen side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Pilpophen Patient Information

Pilpophen Organisms Affected

Humans and other mammals