Pilpophen
Pilpophen Brand names, Pilpophen Analogs
- Allergan
- Aprobit
- Atosil
- Avomine
- Dimapp
- Diphergan
- Diprazine
- Diprozin
- Dorme
- Duplamin
- Fargan
- Fellozine
- Fenazil
- Fenergan
- Fenetazina
- Genphen
- Hiberna
- Histargan
- Iergigan
- Isophenergan
- Isopromethazine
- Lercigan
- Lergigan
- Lilly 1516
- Mymethazine Fortis
- Phargan
- Phenargan
- Phencen
- Phenergan
- Phenergan Fortis
- Phensedyl
- Pilpophen
- Pipolphen
- Proazaimine
- Proazamine
- Procit
- Promazinamide
- Prometasin
- Prometazin
- Prometh Fortis
- Prometh Plain
- Promethacon
- Promethaine
- Promethazin
- Promethazine Hcl
- Promethazine Plain
- Promethegan
- Promethiazine
- Promezathine
- Prorex
- Protazine
- Prothazin
- Prothazine
- Provigan
- Pyrethia
- Pyrethiazine
- Remsed
- Romergan
- Synalgos
- Tanidil
- Thiergan
- Valergine
- Vallergine
- Zipan-25
Pilpophen Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Pilpophen Chemical_Formula
C17H20N2S
Pilpophen RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Pilpophen fda sheet
Pilpophen msds (material safety sheet)
Pilpophen Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Pilpophen Molecular Weight
284.42 g/mol
Pilpophen Melting Point
60oC
Pilpophen H2O Solubility
Freely soluble
Pilpophen State
Solid
Pilpophen LogP
4.946
Pilpophen Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Pilpophen Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Pilpophen Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Pilpophen Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Pilpophen side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Pilpophen Patient Information
Pilpophen Organisms Affected
Humans and other mammals
