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Provigan Brand names, Provigan Analogs

Provigan Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Provigan Chemical_Formula


Provigan RX_link

Provigan fda sheet

Provigan FDA

Provigan msds (material safety sheet)

Provigan Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Provigan Molecular Weight

284.42 g/mol

Provigan Melting Point


Provigan H2O Solubility

Freely soluble

Provigan State


Provigan LogP


Provigan Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Provigan Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Provigan Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Provigan Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Provigan side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Provigan Patient Information

Provigan Organisms Affected

Humans and other mammals