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Pyrethiazine Brand names, Pyrethiazine Analogs

Pyrethiazine Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Pyrethiazine Chemical_Formula


Pyrethiazine RX_link

Pyrethiazine fda sheet

Pyrethiazine FDA

Pyrethiazine msds (material safety sheet)

Pyrethiazine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Pyrethiazine Molecular Weight

284.42 g/mol

Pyrethiazine Melting Point


Pyrethiazine H2O Solubility

Freely soluble

Pyrethiazine State


Pyrethiazine LogP


Pyrethiazine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Pyrethiazine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Pyrethiazine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Pyrethiazine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Pyrethiazine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Pyrethiazine Patient Information

Pyrethiazine Organisms Affected

Humans and other mammals