Tanidil
Brand names,
Tanidil
Analogs
Tanidil
Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Tanidil
Chemical_Formula
C17H20N2S
Tanidil
RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Tanidil
fda sheet
Tanidil
msds (material safety sheet)
Tanidil
Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Tanidil
Molecular Weight
284.42 g/mol
Tanidil
Melting Point
60oC
Tanidil
H2O Solubility
Freely soluble
Tanidil
State
Solid
Tanidil
LogP
4.946
Tanidil
Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Tanidil
Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Tanidil
Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Tanidil
Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Tanidil
side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Tanidil
Patient Information
Tanidil
Organisms Affected
Humans and other mammals