Promethiazine en es it fr

Promethiazine Brand names, Promethiazine Analogs

Promethiazine Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Promethiazine Chemical_Formula


Promethiazine RX_link

Promethiazine fda sheet

Promethiazine FDA

Promethiazine msds (material safety sheet)

Promethiazine Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Promethiazine Molecular Weight

284.42 g/mol

Promethiazine Melting Point


Promethiazine H2O Solubility

Freely soluble

Promethiazine State


Promethiazine LogP


Promethiazine Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Promethiazine Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Promethiazine Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Promethiazine Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Promethiazine side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Promethiazine Patient Information

Promethiazine Organisms Affected

Humans and other mammals