Dorme
Dorme Brand names, Dorme Analogs
- Allergan
- Aprobit
- Atosil
- Avomine
- Dimapp
- Diphergan
- Diprazine
- Diprozin
- Dorme
- Duplamin
- Fargan
- Fellozine
- Fenazil
- Fenergan
- Fenetazina
- Genphen
- Hiberna
- Histargan
- Iergigan
- Isophenergan
- Isopromethazine
- Lercigan
- Lergigan
- Lilly 1516
- Mymethazine Fortis
- Phargan
- Phenargan
- Phencen
- Phenergan
- Phenergan Fortis
- Phensedyl
- Pilpophen
- Pipolphen
- Proazaimine
- Proazamine
- Procit
- Promazinamide
- Prometasin
- Prometazin
- Prometh Fortis
- Prometh Plain
- Promethacon
- Promethaine
- Promethazin
- Promethazine Hcl
- Promethazine Plain
- Promethegan
- Promethiazine
- Promezathine
- Prorex
- Protazine
- Prothazin
- Prothazine
- Provigan
- Pyrethia
- Pyrethiazine
- Remsed
- Romergan
- Synalgos
- Tanidil
- Thiergan
- Valergine
- Vallergine
- Zipan-25
Dorme Brand Names Mixture
- Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)
Dorme Chemical_Formula
C17H20N2S
Dorme RX_link
http://www.rxlist.com/cgi/generic3/phenergan.htm
Dorme fda sheet
Dorme msds (material safety sheet)
Dorme Synthesis Reference
Charpentier, U.S. Pat. 2,503,451 (1950)
Dorme Molecular Weight
284.42 g/mol
Dorme Melting Point
60oC
Dorme H2O Solubility
Freely soluble
Dorme State
Solid
Dorme LogP
4.946
Dorme Dosage Forms
Tablet; Suppository; Opthalmic drops; Syrup
Dorme Indication
For the treatment of allergic disorders, itching, nausea and vomiting.
Dorme Pharmacology
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Dorme Absorption
On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.
Dorme side effects and Toxicity
Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Dorme Patient Information
Dorme Organisms Affected
Humans and other mammals
