Dorme en es it fr

Dorme Brand names, Dorme Analogs

Dorme Brand Names Mixture

  • Phenergan VC Expectorant Syrup (Phenylephrine hydrochloride + Potassium guaiacol sulphonate + Promethazine hydrochloride)

Dorme Chemical_Formula


Dorme RX_link

Dorme fda sheet

Dorme FDA

Dorme msds (material safety sheet)

Dorme Synthesis Reference

Charpentier, U.S. Pat. 2,503,451 (1950)

Dorme Molecular Weight

284.42 g/mol

Dorme Melting Point


Dorme H2O Solubility

Freely soluble

Dorme State


Dorme LogP


Dorme Dosage Forms

Tablet; Suppository; Opthalmic drops; Syrup

Dorme Indication

For the treatment of allergic disorders, itching, nausea and vomiting.

Dorme Pharmacology

Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.

Dorme Absorption

On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance.

Dorme side effects and Toxicity

Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)

Dorme Patient Information

Dorme Organisms Affected

Humans and other mammals